It is reported that researchers from Barcelona have developed a microfluidic chip that can simulate the human blood retinal barrier, and hope to test the effect of drugs on the retina and better study diabetic retinopathy.
At present, the study of the blood-retinal barrier using traditional cell culture techniques does not accurately simulate this unique environment. Researcher Rosa Villa said: "In living organisms, endothelial cells covering the inner wall of blood vessels are susceptible to mechanical signals of blood flow. In cell cultures that do not repeat this condition, we can say that cells are in a 'dormant state' and there is no The reaction that occurs under real conditions."
Therefore, the research team developed a simplified solution, a microfluidic chip that contains cells present in the blood-retinal barrier that enable cellular communication and corresponding mechanical stimulation. Compared to conventional tissue culture flasks, the chip can more accurately display the physiological state of the blood-retinal barrier.
The device contains several parallel compartments that can accommodate different cell types to mimic the layered structure of the retina. Each compartment contains different types of cells, including endothelial cells, neuronal cells, and retinal pigment epithelial cells. As in the entire organ, the device enables intercellular communication, ie cells in different compartments can communicate chemical signals to each other through the microchannels that connect them.
Rafael Simó, another researcher in the study, said: "The most striking feature of this technique is that it mimics the 'in vivo' events that occur in the retina and can therefore be an important tool for promoting in vitro experiments. Cells are constantly passing through the device. The ground grows in contact with the fluid. In addition, the cells maintain a close interaction with each other through the chemical medium."
The team plans to use the device to study the effects of various molecules on the blood-retinal barrier in order to learn more about retinal diseases such as diabetic retinopathy and its treatment.
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